Middle Cerebral Artery Occlusion/Reperfusion Model in Monkeys
نویسندگان
چکیده
This study was designed to develop a reversible middle cerebral artery (MCA) occlusion/reperfusion model in monkeys. By inserting a Cordis steerable guidewires balloon catheter (595-E014) from the femoral artery of 12 male adult monkeys (Macaca mulatta) weighting 5.5±0.5Kg, the balloon catheter could be inserted into the MCA and occluded the blood flow. Magnetic resonance T1, T2 and DWI showed ischemic signals in MCA supplied area. Neurological evaluation demonstrated neurological deficits in the ischemic group. Neuropathological examinations were consistent with the neurological evaluations. The results suggested that this monkey MCAO model seemed close to human stroke.
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